Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5
نویسندگان
چکیده
منابع مشابه
Echinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (IE). Materials and Methods:Western blot assays were performed to determine EML5 expression in 36 su...
متن کاملechinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
objective(s):emap-like protein 5 (eml5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. the aim of this study was to investigate the expression profile of eml5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (ie). materials and methods:western blot assays were performed to determine eml5 expression in 36 sur...
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Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...
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We have shown previously that brain tissue contains protein kinases which can phosphorylate tau protein to a state reminiscent of the pathological state of Alzheimer paired helical filaments (PHFs); these include proline-directed kinases which phosphorylate SP or TP motifs (such as MAP kinase and GSK-3) [Drewes et al. (1992); Mandelkow et al. (1992)], as well as a novel kinase which phosphoryla...
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Tau is an intrinsically unstructured microtubule (MT)-associated protein capable of binding to and organizing MTs into evenly spaced parallel assemblies known as "MT bundles." How tau achieves MT bundling is enigmatic because each tau molecule possesses only one MT-binding region. To dissect this complex behavior, we have used a surface forces apparatus to measure the interaction forces of the ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2003
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2004.02147.x